Discovery of recurrent structural variants in nasopharyngeal
نویسندگان
چکیده
Material Supplemental http://genome.cshlp.org/content/suppl/2013/11/21/gr.156224.113.DC1.html P<P Published online November 8, 2013 in advance of the print journal. Preprint Accepted likely to differ from the final, published version. Peer-reviewed and accepted for publication but not copyedited or typeset; preprint is License Commons Creative . http://creativecommons.org/licenses/by-nc/3.0/ described at a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as ). After six months, it is available under http://genome.cshlp.org/site/misc/terms.xhtml first six months after the full-issue publication date (see This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the
منابع مشابه
Discovery of recurrent structural variants in nasopharyngeal carcinoma.
We present the discovery of genes recurrently involved in structural variation in nasopharyngeal carcinoma (NPC) and the identification of a novel type of somatic structural variant. We identified the variants with high complexity mate-pair libraries and a novel computational algorithm specifically designed for tumor-normal comparisons, SMASH. SMASH combines signals from split reads and mate-pa...
متن کاملThe importance of the optimal volume in the treatment of locally recurrent nasopharyngeal carcinoma; brachytherapy or stereotactic radiotherapy?
Introduction: Nasopharyngeal carcinoma (NPC) is commonly known as a radiosensitive tumor with the initial good response to radiation. Despite the improved outcome in loco regional control by the introduction of combining treatment, modern radiotherapy techniques and enhanced imaging studies, local recurrent after primary treatment with rate ranges from 15-58% in 5 years, stil...
متن کاملP-200: Frequency of Heterochromatin Polymorphisms in Couples with Recurrent Abortions in Patients Refer to IVF Clinic of Yazd
Background: Recurrent pregnancy loss (RPL) is a multifactorial problem associated with genetic abnormalities reflected by inherited disorders. The aim of the present study was to investigate the contribution of heterochromatin polymorphism in couples with recurrent miscarriages compared with couples without miscarriages. Materials and Methods: Over a 3 year period, we made a study of the diagno...
متن کاملThe forgotten role of methenamine to prevent recurrent urinary tract infection: urgency for reuse 100 years after discovery
In conclusion, UTI is a globally distributed disease with emergence of multidrug-resistant bacteria; thus, new drug discovery or activation of previously used drugs is an urgent issue. Methenamine has been suggested as a beneficial agent for the UTI prevention as it works as a urinary antiseptic by safely producing formaldehyde to prevent bacterial growth while avoiding bacterial resistance...
متن کاملAnalysis of Missense Mutations of CX3CR1 Gene in Patients with Recurrent Pregnancy Loss Using Bioinformatics Tools
Introduction: Abortion is a common complication that refers to the early termination of pregnancy with the death of the fetus before the 20th week of pregnancy. Previous studies show that many genes are involved in this disease, including the CX3CR1 gene, which is one of the inflammatory response genes in the immune system. The pathogenicity of these variants was determined in this study using ...
متن کامل